Liver & Kidney Profile (9+4)
A focused veterinary chemistry panel for liver injury, bilirubin handling, renal filtration, hydration/protein status, and glucose screening, combining 9 measured analytes with 4 calculated indicators in one run.
High-value clinical uses
Useful for first-line workups in vomiting, anorexia, lethargy, jaundice concern, dehydration, suspected azotemia, pre-anesthetic checks, and routine internal medicine monitoring.
Core coverage
Protein balance, hepatocellular leakage markers, biliary support marker, bilirubin burden, renal filtration markers, and glucose assessment in a compact profile.
Platform workflow
Structured for the Celercare V / Pointcare V chemistry analyzer family using dry chemistry disc workflow and barcode-based calibration.
What this panel is for
The Liver & Kidney Profile (9+4) is designed as a streamlined veterinary chemistry panel for screening the two organ systems most frequently checked in daily practice: the liver and the kidneys. In practical use, it helps assess hepatocellular injury, bilirubin handling, biliary involvement through GGT, renal filtration through creatinine and BUN, hydration/protein status through total protein and albumin, and glucose disturbances that may complicate hepatic, renal, endocrine, or critical illness cases.
Measured test items (9)
Calculation items (4)
*Calculated indicators help pattern recognition and screening efficiency, but they are not stand-alone diagnoses.
Sample, workflow, and handling
Specimen
Use serum or lithium heparin plasma on the shared Celercare V / Pointcare V chemistry platform family.
Sample volume
Shared platform workflows in the related chemistry profile IFUs use 100 μL sample input per reagent disc.
Timing
Prompt sample handling is recommended. Where the same platform workflow applies, testing should begin soon after sample transfer to the disc and routine chemistry pre-analytical delays should be minimized.
Disc storage
For related chemistry discs on this analyzer family, sealed reagent discs are stored refrigerated and protected from heat, moisture, and direct sunlight.
- Glucose: delayed separation from cells can falsely lower glucose.
- Bilirubin: light exposure can reduce measured bilirubin and create falsely lower results.
- AST: interpret alongside ALT and clinical context because AST can increase with muscle injury as well as liver injury.
Clinical interpretation by analyte group
Protein profile
TP, ALB, GLO, and ALB/GLO help evaluate hydration, protein loss, inflammatory globulin increases, and reduced hepatic synthetic support. A high total protein can simply reflect hemoconcentration, so it should always be read with albumin and calculated globulin.
Hepatic injury and bilirubin handling
ALT and AST are leakage or injury markers, not pure function markers. GGT adds biliary/cholestatic support, while TBIL reflects bilirubin burden from hemolysis, impaired hepatic handling, or cholestasis.
Renal and hydration assessment
CRE, BUN, and BUN/CRE support screening for reduced filtration, dehydration, prerenal azotemia, and disproportionate urea changes from GI bleeding or catabolism.
Glucose assessment
GLU adds metabolic and emergency value by flagging stress hyperglycemia, diabetes mellitus, severe systemic disease, sepsis, insulin excess, or hepatic compromise when interpreted with the rest of the profile.
Quick high / low interpretation guide
| Analyte | Main intent of use | When high may suggest | When low may suggest / key notes |
|---|---|---|---|
| TP | Hydration and protein screening | Dehydration, hyperglobulinemia | Protein loss, hemorrhage, dilution; always interpret with ALB and GLO |
| ALB | Oncotic support, hepatic synthesis, loss | Usually dehydration | Protein loss, reduced synthesis, dilution |
| ALT | Hepatocellular leakage/injury | Hepatocellular injury | Low values are usually not clinically important |
| AST | Liver or muscle injury support | Hepatic injury or muscle injury | Interpret with ALT and clinical context; low values rarely matter |
| GGT | Biliary / cholestatic support | Cholestasis or biliary epithelial disease | Low values usually not significant |
| TBIL | Bilirubin burden | Cholestasis, hemolysis, impaired hepatic handling | Protect sample from light; low values usually not significant |
| CRE | Filtration marker | Decreased GFR, renal or postrenal causes | May be lower with low muscle mass |
| BUN | Renal and protein metabolism screening | Prerenal azotemia, renal disease, GI bleeding, catabolism | Low protein intake, hepatic dysfunction, dilution |
| GLU | Metabolic and emergency screening | Stress hyperglycemia, diabetes mellitus, endocrine disease | Sepsis, insulin excess, severe hepatic dysfunction, delayed sample separation |
| GLO* | Inflammatory and immune protein estimate | Inflammation, chronic antigenic stimulation, gammopathy | Protein loss or low globulin states |
| ALB/GLO* | Protein pattern balance | Relative globulin depletion | Relative globulin excess or albumin loss |
| AST/ALT* | Pattern clue only | Disproportionately higher AST can increase concern for muscle contribution or more mixed injury pattern | Not diagnostic alone |
| BUN/CRE* | Disproportion clue | BUN disproportionately high in dehydration, GI bleeding, or catabolism | Lower ratio may fit reduced urea production or relatively higher creatinine |
Pattern-based diagnostic scenarios
1) Dehydration / prerenal trend
TP and albumin high-normal or increased, with BUN rising more than creatinine. This pattern fits volume depletion better than primary renal failure when supported by history, exam, and urine concentration.
2) Hepatocellular injury
ALT and AST increased, with bilirubin normal or increased. This suggests hepatocyte injury or leakage, but not automatically hepatic failure.
3) Cholestatic / bilirubin-handling problem
GGT and bilirubin increased, sometimes with milder ALT or AST changes. This pattern raises concern for biliary disease, cholestasis, or impaired hepatic bilirubin processing.
4) Hepatic synthetic concern or chronic liver disease support
Low albumin with low BUN and possibly low glucose can support reduced hepatic synthetic or metabolic capacity, especially when dehydration is not present.
5) Renal compromise / azotemia
Creatinine and BUN rise together. This supports reduced filtration, but urinalysis and imaging are still needed to distinguish prerenal, renal, and postrenal causes.
6) GI bleeding or strong catabolic state
BUN increases out of proportion to creatinine, often with compatible clinical signs. The BUN/CRE relationship is a clue, not a diagnosis by itself.
7) Inflammatory protein pattern
Total protein may be normal or increased while albumin decreases and globulin rises, lowering the ALB/GLO ratio. This pattern supports chronic inflammation or immune stimulation.
8) Stress hyperglycemia vs diabetes concern
Isolated glucose elevation may reflect stress, but persistent or marked hyperglycemia, especially with compatible history, should prompt a full diabetes workup.
Reference intervals (guideline values for overlapping analytes on the shared platform family)
These guideline intervals are drawn from related chemistry analyzer IFUs for overlapping analytes and should be treated as platform-family references, not a substitute for panel-specific laboratory intervals.
| Analyte | Dog | Cat |
|---|---|---|
| TP | 5.2-8.2 g/dL | 5.4-8.9 g/dL |
| ALB | 2.2-4.4 g/dL | 2.2-4.5 g/dL |
| ALT | 10-140 U/L | 8.2-123 U/L |
| AST | 8.9-55 U/L | 9.2-60 U/L |
| GGT | 0-7 U/L | 0-2 U/L |
| TBIL | 0.1-0.9 mg/dL | 0.1-0.9 mg/dL |
| CRE | 0.3-1.7 mg/dL | 0.3-2.5 mg/dL |
| BUN | 7-32 mg/dL | 10-43 mg/dL |
| GLU | 70-143 mg/dL | 74-159 mg/dL |
Interference, reporting, and performance notes
Sample flags
On related chemistry analyzer discs, hemolysis, lipemia, and icterus can affect measured values. Results with significant interference may be suppressed and reported as HEM, LIP, or ICT instead of numeric values.
Bilirubin and glucose caution
Bilirubin can decline with light exposure, and glucose can decline in samples that remain on cells too long before separation. Good pre-analytical handling matters for this profile.
AST interpretation
AST is not liver-specific. If AST is disproportionately high compared with ALT, review for muscle injury, hemolysis, or delayed sample processing as well as liver disease.
Focused-panel caution
This is a compact profile. It does not replace a broader chemistry or urinalysis when electrolyte, mineral, acid-base, pancreatic, or bile acid detail is clinically necessary.
Why this profile is valuable
This profile gives fast screening value with minimal complexity: it covers the most commonly requested liver and kidney chemistry markers while still adding protein interpretation and glucose context. That makes it useful for baseline screening, follow-up monitoring, and rapid decision-making when a full broad chemistry panel is not required.
References
Primary product / IFU reference
- Tianjin MNCHIP Technologies Co., Ltd. Celercare V / Pointcare V chemistry analyzer IFU. Used for shared platform workflow style, specimen handling principles, and overlapping analyte guideline intervals from related chemistry profiles.